Frank Lampard has made four changes to the side which faced Aston Villa before the international break.
The boss has been handed a boost with the return of midfielder Mason Mount who replaces Tom Lawrence in midfield.
However, the boss has been forced to make a number of enforced changes with Scott Malone and Florian Jozefzoon replacing the injured Craig Forsyth and Mason Bennett.
Jayden Bogle misses the game through illness and is replaced at right back by Andre Wisdom who comes in for his first start since the league victory against Hull at the start of September.
Richard Keogh will captain the Rams this afternoon, whilst Jack Marriott leads the attack.
Here are the teams:
Sheffield Wednesday: Dawson, Fox, Pelupessy, Bannan, Lees, Joao, Matias, Reach, Baker, Hector, Forestieri.
Substitutes: Wildsmith, Palmer, Onomah, Thorniley, Nuhiu, Pudil, Penney.
Derby County: Carson, Wisdom, Tomori, Keogh ©, Malone, Huddlestone, Holmes, Wilson, Mount, Jozefzoon, Marriott.
Substitutes: Roos, Davies, Pearce, Johnson, Bryson, Lawrence, Waghorn.